Injection site rotation, done properly

Injecting the same spot over and over irritates tissue, can thicken or scar the skin (lipohypertrophy), and makes absorption less predictable. Rotation is the fix, and it costs nothing — the only hard part is remembering where you injected last Tuesday.

The eight standard subcutaneous sites

• Abdomen, left and right — a hand's width from the navel; the most common choice
• Thighs, left and right — front-outer mid-thigh
• Glutes, left and right — upper-outer quadrant
• Deltoids, left and right — the fatty area over the shoulder

Daily protocols cycle through all eight in about a week. Twice-daily protocols reach each site roughly every four days — still a meaningful rest if the rotation is actually followed.

What a good rotation looks like

There are two workable systems:

1. Fixed order. Abdomen L → abdomen R → thigh L → thigh R → glute L → glute R → delt L → delt R, repeat. Simple, but breaks the moment you skip a dose or can't reach a site.
2. Longest-rested-first. Always inject the site that has gone the longest without use. This self-heals around skipped doses and site preferences — and it's what PepShot computes automatically.

Signals a site needs more rest

Lingering redness, firmness, lumps, or soreness at a site are all reasons to leave it alone longer and to mention it to your clinician. Logging a quick note with the dose ("slight redness, iced it") turns vague memories into a pattern you can actually see.

Why tracking beats memory

Nobody reliably remembers eight sites across two compounds and fourteen doses a week. A rotation log shows rest days per site at a glance — green when rested, amber under a week, red under three days — and that glance is all it takes to protect tissue for a protocol that runs months.

A body map that remembers for you

PepShot tracks rest time for all eight sites on a visual body map and suggests the longest-rested one at every log. No notebook, no guessing.

Download PepShot

Related: how to reconstitute · GLP-1 tracking